Although we usually think of calorie cut as an attempt to take advantage of our favorite partner of thin jeans, it is worth remembering that scientists think in terms of longevity more than looks.
It has long been known that reducing the calorie intake severely can extend the life, which is why the intermittent fasting has become all anger.
However, even the most disciplined between us would admit that it is not “sustainable”, which is a great way to say that it is scary.
Now, a new UK study suggests that you can have your cake and eat it too, so to say.
A massive analysis recently published in Aging Cell magazine revealed that rapamycin – the immunosuppressive drug turned the Darling longevity – gives almost the same benefits as life as the calories of life.
“Dietary restriction, for example, through intermittent fasting or reduction of calorie intake, has been the Golden Standard to live longer. But it is difficult for most of us to keep in the long term,” said Dr. Zahida Sultanova, a researcher at the University of Esta Anglia, said in a statement.
“We wanted to know if popular anti-aging drugs such as rapamycin or metformin could offer similar effects without having to cut calories.”
Researchers analyzed 167 studies on eight vertebrate species (including primates, rodents and fish) to find that rapamycin results were surprisingly similar to rigorous dietary restriction.
The same findings were not maintained for the popular metformin of type 2 diabetes.
Rapamycin, isolated from the soil on Easter Island in the 1970’s, was originally used to suppress the immune response in patients with organ transplantation and treat rare diseases.
It works inhibiting the MTOR path, which governs the growth and repair of cells, and seems to imitate cell cleaning triggered by fasting, known as autophage.
Although rapamycin is already approved by food and drug administration for other uses, it is not erased for anti -eve of humans.
Although the low doses of the drug do not seem to have serious side effects, some studies suggest that because it suppresses the immune system, it can increase the risk of infection.
Other common side effects are headache, chills, joint pain, diarrhea, nausea and sores in the mouth.
The 47-year-old Acolith Anti-Avengership, 47, confessed last year that he dropped the drug of his routine after years of experimentation because “the advantages of rapamycin’s lifetime dosage do not justify the side effects”.
He reported occasional skin and soft tissue infections, abnormal amounts of blood fat, increased blood sugar, and a larger heart rate.
The study co-author, Dr. Edward Ivimey-Cook, said that these new research finds do not suggest that everyone should start taking rapamycin.
“But they reinforce the case for their subsequent study of aging research and raise important issues on how to address therapeutic longevity,” he said.
Sultanova added that the results “show that drug replacement is a promising approach to improving the health and life of people.”
The new article makes a persuasive case that rapamycin rivaling with calorie restriction as a longevity strategy.
But until large -scale human trials show that it is safe and effective for everyday use, you must keep -in healthy eating, exercises and life changes proved to try to live longer.
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